Wiwanitkit Viroj
Wiwanitkit House, Bangkhae, Bangkok-10160, Thailand.
Indian J Hum Genet. 2013 Jul;19(3):291-2. doi: 10.4103/0971-6866.120812.
Hemoglobin (Hb) D Punjab disorder is a congenital hemoglobinopathy described in India. It is a disorder due to defect in beta-globin gene.
Here, the author assesses the possibility of U7.623 gene therapy for Hb D Punjab disorder. A standard bioinformatic analysis to study the effect of co-expression between nucleic acid sequence for human Hb D Punjab beta-globin chain and U7.623 was performed.
It can be seen that fully recovery of Hb function and biological process can be derived via gene ontology study.
Here, there is a rationale to use U7 small nuclear ribonucleic acid as a possible tool for gene therapy in Hb D Punjab disorder.
血红蛋白D（Hb）旁遮普紊乱症是一种在印度被描述的先天性血红蛋白病。它是一种由于β-珠蛋白基因缺陷导致的疾病。
在此，作者评估了U7.623基因疗法治疗Hb旁遮普紊乱症的可能性。进行了一项标准的生物信息学分析，以研究人类Hb旁遮普β-珠蛋白链核酸序列与U7.623共表达的效果。
通过基因本体研究可以看出，Hb功能和生物学过程能够完全恢复。
在此，有理由将U7小核核糖核酸用作治疗Hb旁遮普紊乱症的一种可能的基因治疗工具。
