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工程化蛋白质图案化胶体粒子的介电泳性质。

Dielectrophoretic properties of engineered protein patterned colloidal particles.

机构信息

LTM, CNRS-UJF, CEA-LETI, 17 av. des Martyrs, 38054 Grenoble, France.

出版信息

Biomicrofluidics. 2012 Dec 12;6(4):44115. doi: 10.1063/1.4771544. eCollection 2012.

Abstract

This work determines the dielectrophoretic response of surface modified polystyrene and silica colloidal particles by experimentally measuring their Clausius-Mossotti factors. Commercial charged particles, fabricated ones coated with fibronectin, and Janus particles that have been grafted with fibronectin on one side only were investigated. We show that the dielectrophoretic response of such particles can be controlled by the modification of the chemistry or the anisotropy of their surface. Moreover, by modelling the polarizabilities of those particles, the dielectric parameters of the particles and the grafted layer of protein can be measured.

摘要

本工作通过实验测量其克劳修斯-莫索蒂因子来确定表面改性聚苯乙烯和二氧化硅胶体颗粒的介电泳响应。研究了商业带电粒子、涂有纤连蛋白的自制粒子和只有一侧接枝有纤连蛋白的两性粒子。我们表明,通过修饰其化学性质或表面各向异性,可以控制此类粒子的介电泳响应。此外,通过对这些粒子的极化率进行建模,可以测量粒子和接枝蛋白层的介电参数。

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