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视网膜神经胶质细胞膜的区域特化及其对钾离子空间缓冲的重要性。

Regional specialization of the membrane of retinal glial cells and its importance to K+ spatial buffering.

作者信息

Newman E A

出版信息

Ann N Y Acad Sci. 1986;481:273-86. doi: 10.1111/j.1749-6632.1986.tb27158.x.

DOI:10.1111/j.1749-6632.1986.tb27158.x
PMID:2434012
Abstract

Electrophysiological experiments, obtained primarily from dissociated salamander cells, demonstrate that the K+ conductance of Müller cells is distributed in a highly nonuniform manner over the cell surface. A large fraction of the total cell conductance is localized to that portion of the endfoot process that faces the vitreous humor. Along the remainder of the cell, specific K+ conductance is larger in the outer plexiform layer than in neighboring regions. High-endfoot conductance directs K+ spatial buffering currents preferentially through the endfoot process, leading to an efficient form of spatial buffering termed K+ siphoning. Preliminary experiments suggest that the endfeet of astrocytes also have high K+ conductance.

摘要

主要从分离的蝾螈细胞获得的电生理实验表明,米勒细胞的钾离子电导在细胞表面以高度不均匀的方式分布。细胞总电导的很大一部分位于面向玻璃体的终足突的那部分。沿着细胞的其余部分,外网状层的特定钾离子电导比相邻区域更大。高终足电导优先引导钾离子空间缓冲电流通过终足突,导致一种称为钾离子虹吸的高效空间缓冲形式。初步实验表明,星形胶质细胞的终足也具有高钾离子电导。

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Regional specialization of the membrane of retinal glial cells and its importance to K+ spatial buffering.视网膜神经胶质细胞膜的区域特化及其对钾离子空间缓冲的重要性。
Ann N Y Acad Sci. 1986;481:273-86. doi: 10.1111/j.1749-6632.1986.tb27158.x.
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Distribution of potassium conductance in mammalian Müller (glial) cells: a comparative study.哺乳动物米勒(神经胶质)细胞中钾离子电导的分布:一项比较研究。
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Endfeet of retinal glial cells have higher densities of ion channels that mediate K+ buffering.视网膜神经胶质细胞的终足具有更高密度的介导钾离子缓冲的离子通道。
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