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Science. 1984 Sep 14;225(4667):1174-5. doi: 10.1126/science.6474173.
2
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本文引用的文献

1
Analysis of potassium dynamics in mammalian brain tissue.哺乳动物脑组织中钾动力学分析。
J Physiol. 1983 Feb;335:393-426. doi: 10.1113/jphysiol.1983.sp014541.
2
Regional specialization of retinal glial cell membrane.视网膜神经胶质细胞膜的区域特化
Nature. 1984;309(5964):155-7. doi: 10.1038/309155a0.
3
Model of electroretinogram b-wave generation: a test of the K+ hypothesis.视网膜电图b波产生模型:钾离子假说的验证
J Neurophysiol. 1984 Jan;51(1):164-82. doi: 10.1152/jn.1984.51.1.164.
4
Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.神经冲动对两栖动物中枢神经系统中神经胶质细胞膜电位的影响。
J Neurophysiol. 1966 Jul;29(4):788-806. doi: 10.1152/jn.1966.29.4.788.
5
The equilibration time course of (K + ) 0 in cat cortex.猫皮层中(K⁺)₀的平衡时间进程。
Exp Brain Res. 1973 Apr 30;17(2):190-205. doi: 10.1007/BF00235028.
6
Neuroglial cells: physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential.神经胶质细胞:生理特性以及神经元活动对胶质细胞膜电位的钾介导效应。
Proc R Soc Lond B Biol Sci. 1967 Jun 6;168(1010):1-21. doi: 10.1098/rspb.1967.0047.
7
Fast recording ion specific microelectrodes: their use in pharmacological studies in the CNS.快速记录离子特异性微电极:其在中枢神经系统药理学研究中的应用。
Neuropharmacology. 1974 Jun;13(6):509-17. doi: 10.1016/0028-3908(74)90140-3.
8
Light-evoked potassium activity in mudpuppy retina: its relationship to the b-wave of the electroretinogram.泥螈视网膜中光诱发的钾离子活动:其与视网膜电图b波的关系。
Brain Res. 1978 Oct 13;154(2):388-94. doi: 10.1016/0006-8993(78)90711-4.
9
Laminar separation of light-evoked K+ flux and field potentials in frog retina.蛙视网膜中光诱发钾离子通量与场电位的层流分离
Invest Ophthalmol Vis Sci. 1978 Jul;17(7):678-82.
10
Generation of b-wave currents in the skate retina.鳐鱼视网膜中b波电流的产生。
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5727-31. doi: 10.1073/pnas.75.11.5727.

视网膜神经胶质细胞通过钾离子虹吸作用对细胞外钾离子水平进行调控。

Control of extracellular potassium levels by retinal glial cell K+ siphoning.

作者信息

Newman E A, Frambach D A, Odette L L

出版信息

Science. 1984 Sep 14;225(4667):1174-5. doi: 10.1126/science.6474173.

DOI:10.1126/science.6474173
PMID:6474173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2693189/
Abstract

Efflux of K+ from dissociated salamander Müller cells was measured with ion-selective microelectrodes. When the distal end of an isolated cell was exposed to high concentrations of extracellular K+, efflux occurred primarily from the endfoot, a cell process previously shown to contain most of the K+ conductance of the cell membrane. Computer simulations of K+ dynamics in the retina indicate that shunting ions through the Müller cell endfoot process is more effective in clearing local increases in extracellular K+ from the retina than is diffusion through extracellular space.

摘要

用离子选择性微电极测量了离体蝾螈Müller细胞的钾离子外流。当分离细胞的远端暴露于高浓度细胞外钾离子时,外流主要发生在终足,终足是一种细胞突起,先前已证明其包含细胞膜大部分的钾离子电导。视网膜中钾离子动力学的计算机模拟表明,通过Müller细胞终足突起分流离子,比通过细胞外空间扩散,能更有效地清除视网膜局部细胞外钾离子的增加。