Kim Sang Ho, Park Chang Hwan, Ki Ho Seok, Jun Chung Hwan, Park Seon Young, Kim Hyun Soo, Choi Sung Kyu, Rew Jong Sun
Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Clin Endosc. 2013 Nov;46(6):656-61. doi: 10.5946/ce.2013.46.6.656. Epub 2013 Nov 19.
Duodenal neuroendocrine tumors (NETs) are rare neoplasms. In this study, the medical records of 14 patients with duodenal NETs diagnosed at Chonnam National University Hospital from July 2001 to August 2011 were reviewed and analyzed retrospectively. Four patients were diagnosed in the first 5 years, and 10 patients were diagnosed in the latter 5 years of the study. Ten of 12 patients (83.3%) who underwent endoscopic biopsy were confirmed to have NET before resection. Endoscopic resection was performed in 12 patients, surgical resection in one patient, and regular follow-up in one patient who refused resection. None of the patients showed recurrence or distant metastasis. Duodenal NETs are increasingly observed and are mostly detected during screening upper gastrointestinal endoscopy. Careful endoscopic examination and biopsy can improve the diagnostic yield of NETs. Most well-differentiated, nonfunctional duodenal NETs that are limited to the mucosa/submucosa can be treated effectively with endoscopic resection.
十二指肠神经内分泌肿瘤（NETs）是罕见的肿瘤。在本研究中，回顾并分析了2001年7月至2011年8月在全南国立大学医院诊断为十二指肠NETs的14例患者的病历。4例患者在研究的前5年被诊断，10例患者在研究的后5年被诊断。12例行内镜活检的患者中有10例（83.3%）在切除前被确诊为NET。12例患者行内镜切除，1例患者行手术切除，1例拒绝切除的患者进行定期随访。所有患者均未出现复发或远处转移。十二指肠NETs的检出率越来越高，大多是在筛查上消化道内镜检查时发现的。仔细的内镜检查和活检可提高NETs的诊断率。大多数局限于黏膜/黏膜下层的高分化、无功能十二指肠NETs可通过内镜切除得到有效治疗。
