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[金黄色葡萄球菌引起的急性肠道感染的流行病学-生物学特征]

[Epidemiology-biological features of the acute intestinal infections caused by Staphylococcus aureus].

作者信息

Golubnichaia V N, Malysh N G

出版信息

Vestn Ross Akad Med Nauk. 2013(8):24-7.

PMID:24340641
Abstract

Nowadays the structure of acute intestinal infections pathogens changed substantially. It is caused by constant evolution of bacteria and involvement of the opportunistic pathogens in the pathological processes. The aim of the study was to investigate the prevalence of the acute intestinal infections caused by staphylococci in the North-Eastern region of Ukraine, to determine the pathogenic factors in isolated pathogens. The materials for the study were the data of statistical reporting of Sumy regional sanitary-epidemiological station. Biological properties of the 50 Staphylococcus aureus strains were investigated. In the work used The descriptive and analytical techniques of the epidemiological, bacteriological and statistical methods were used. In the 2007-2012 the incidence of acute intestinal infections caused by staphylococci was in the range 17,1-20,3 on the 100 thousand. 2 years children were prevailed in the age structure. The largest numbers of cases were recorded in January, February, April, June and August. Strains of Staphylococcus aureus, isolated from the patients were characterized by a wide spectrum of pathogenic and persistence factors. Anti-lisozym activity was in 100% of the investigated cultures, anti-interferon and anti-complement activity were detected in 96,0 and 64,0% stains, ability to adhesion was present in 36,0% stains. At the same time anti-lisozym, anti-interferon and anti-complement activity were showed in the 52,0% stains of the Staphylococcus aureus. These data characterize negatively predicted for the near future regional trends in morbidity.

摘要

如今,急性肠道感染病原体的结构发生了重大变化。这是由细菌的不断进化以及机会性病原体参与病理过程所导致的。本研究的目的是调查乌克兰东北部地区由葡萄球菌引起的急性肠道感染的流行情况,确定分离出的病原体中的致病因素。研究材料为苏梅地区卫生流行病学站的统计报告数据。对50株金黄色葡萄球菌的生物学特性进行了研究。在这项工作中使用了流行病学、细菌学和统计学方法的描述性和分析性技术。在2007 - 2012年期间,由葡萄球菌引起的急性肠道感染发病率为每10万人中17.1 - 20.3例。年龄结构中以2岁儿童居多。病例数最多的记录出现在1月、2月、4月、6月和8月。从患者身上分离出的金黄色葡萄球菌菌株具有广泛的致病和持久因素。在所研究的培养物中,100%具有抗溶菌酶活性,在96.0%和64.0%的菌株中检测到抗干扰素和抗补体活性,36.0%的菌株具有黏附能力。同时,在52.0%的金黄色葡萄球菌菌株中显示出抗溶菌酶、抗干扰素和抗补体活性。这些数据对该地区近期的发病趋势作出了负面预测。

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