Zhu Yuan-Yuan, Wang Cheng, Zhang Chun-Ni
Department of Clinical Laboratory, PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2013 Nov;19(11):1039-42.
MicroRNAs (miRNAs), present abundantly in human body fluids, may serve as biomarkers for the diagnosis of a variety of diseases. Recent studies show that they are also abundantly and stably expressed in the seminal plasma of men. Some seminal plasma-specific miRNAs can be used as potential markers for forensic body fluid identification. Furthermore, the expression profile of seminal plasma miRNAs in normal fertile men is quite different from that in idiopathic infertile patients. The specifically altered profile of seminal plasma miRNA is closely related with male infertility and spermatogenic dysfunction and therefore can be used as a novel biomarker for the diagnosis of male infertility. A deeper insight into the specific changes of seminal miRNA may point a new direction in the studies of the molecular mechanisms of male infertility.
微小RNA（miRNA）大量存在于人体体液中，可能作为多种疾病诊断的生物标志物。最近的研究表明，它们在男性精液中也大量且稳定地表达。一些精液特异性miRNA可作为法医体液鉴定的潜在标志物。此外，正常生育男性精液中miRNA的表达谱与特发性不育患者有很大不同。精液miRNA的特异性改变谱与男性不育和生精功能障碍密切相关，因此可作为诊断男性不育的新型生物标志物。对精液miRNA具体变化的更深入了解可能为男性不育分子机制的研究指明新方向。
