University of Toronto, Toronto, Ontario, Canada and Cornell University, Ithaca, NY, USA.
Immunotherapy. 2014;6(1):51-7. doi: 10.2217/imt.13.150.
Recent research has provided strong support for the utility of broadly neutralizing antibodies generated against viruses, which inherently possess a high degree of antigenic variability (such as influenza virus or HIV) as a feasible means to prevent infection. Many of these antibodies share the ability to bind to highly conserved regions within the stem of the virus 'spike' or surface glycoprotein, in such a way that they interfere with virus entry, including membrane fusion. As a result, broadly neutralizing antibodies could be supplied to patients as a form of passive immunotherapy, as well as play a role in the design of new 'universal' vaccines and antiviral agents. The following article describes the most recent innovations in this exciting field.
最近的研究为利用针对具有高度抗原变异性的病毒（如流感病毒或 HIV）产生的广泛中和抗体作为预防感染的可行手段提供了有力支持。这些抗体中的许多都具有与病毒“刺突”或表面糖蛋白茎内高度保守区域结合的能力，从而干扰病毒进入，包括膜融合。因此，广泛中和抗体可以作为一种被动免疫疗法提供给患者，并在新的“通用”疫苗和抗病毒药物的设计中发挥作用。本文描述了这一令人兴奋的领域的最新创新。
