Department of Laboratory Medicine and Pathology, The Mayo Clinic, 200 1st St SW, Rochester, Minnesota 55901; Division of Hematopathology, The Mayo Clinic, Rochester, Minnesota.
Department of Laboratory Medicine and Pathology, The Mayo Clinic, 200 1st St SW, Rochester, Minnesota 55901; Division of Hematopathology, The Mayo Clinic, Rochester, Minnesota; Division of Laboratory Genetics, The Mayo Clinic, Rochester, Minnesota.
Semin Diagn Pathol. 2013 Nov;30(4):382-92. doi: 10.1053/j.semdp.2013.11.006. Epub 2013 Nov 12.
The field of diagnostic hematopathology is dynamic and evolving given the ongoing accumulation of molecular information and demand for integration of this information into routine clinical practice. In light of this molecular revolution, the appropriate and effective utilization of molecular studies by clinicians/pathologists is of paramount importance to the current diagnosis, prognosis, and monitoring of nearly all hematologic diseases. In the routine workup of certain hematologic neoplasms, it is more pertinent and practical to understand the purpose of these analyses and how to generally apply them to particular diseases rather than trying to remember a likely outdated list of genes. We will see advances in the treatment of hematologic malignancies as drug development catches up to our molecular understanding of diseases.
鉴于分子信息的不断积累以及将这些信息纳入常规临床实践的需求，诊断血液病理学领域正在不断发展和演变。鉴于这场分子革命，临床医生/病理学家正确有效地利用分子研究对于当前诊断、预后和监测几乎所有血液疾病至关重要。在某些血液肿瘤的常规检查中，了解这些分析的目的以及如何将它们一般应用于特定疾病，而不是试图记住可能过时的基因列表，更为相关和实用。随着药物研发跟上我们对疾病的分子认识，血液恶性肿瘤的治疗将会取得进展。
