Chen Zhong, Sandberg Avery A
Cytogenetics Laboratory, Room 1C210 SOM, Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
Am J Med Genet. 2002 Oct 30;115(3):130-41. doi: 10.1002/ajmg.10689.
The field of molecular cytogenetics has had a great impact on many aspects of medical and basic sciences. During the past 30 years, the application of molecular cytogenetic methodologies has resulted in remarkable advances in the field of cancer genetics and cytogenetics. These advances have led to the establishment of chromosome patterns as diagnostic and prognostic indexes in an array of acute and chronic leukemias and lymphomas, as key information in BMT, and as guides for the localization of oncogenes and tumor suppressor genes that are apparently responsible for the development of neoplastic states. With such information, the physician is in a more favorable position to devise therapy, appraise diagnosis, and plan follow-up.
分子细胞遗传学领域已对医学和基础科学的诸多方面产生了重大影响。在过去30年里，分子细胞遗传学方法的应用在癌症遗传学和细胞遗传学领域取得了显著进展。这些进展已使染色体模式得以确立，作为一系列急性和慢性白血病及淋巴瘤的诊断和预后指标、骨髓移植中的关键信息，以及显然对肿瘤状态发展负责的癌基因和肿瘤抑制基因定位的指导。有了这些信息，医生在制定治疗方案、评估诊断和规划随访方面处于更有利的地位。
