Ala-Houhala I, Pasternack A
Clin Sci (Lond). 1987 Mar;72(3):289-96. doi: 10.1042/cs0720289.
The renal clearance of dextran and protein of different molecular sizes has been measured in 42 proteinuric patients with diabetes and glomerulonephritis. In both patient groups the fractional low molecular (radii 3.0-3.6 nm) dextran clearances were significantly decreased whereas the fractional high molecular (radii 5.1-7.8 nm) dextran clearances were increased as compared with the controls. A porosity/charge index was constructed by calculating the ratio of fractional clearances of neutral to anionic macromolecules (theta D3.6/theta ALB, theta D5.1/theta IgG). In diabetic patients the relation between the fractional clearances of neutral and anionic macromolecules was dependent on glomerular filtration rate. It seems likely that the altered glomerular permeability in diabetic nephropathy is associated with a decrease of charge as renal function deteriorates. In glomerulonephritis the process is different and there is a high degree of variation from case to case.
在42例患有糖尿病和肾小球肾炎的蛋白尿患者中，测量了不同分子大小的右旋糖酐和蛋白质的肾清除率。与对照组相比，在这两组患者中，低分子（半径3.0 - 3.6纳米）右旋糖酐的分数清除率显著降低，而高分子（半径5.1 - 7.8纳米）右旋糖酐的分数清除率则升高。通过计算中性与阴离子大分子的分数清除率之比（θD3.6/θALB，θD5.1/θIgG）构建了孔隙率/电荷指数。在糖尿病患者中，中性和阴离子大分子的分数清除率之间的关系取决于肾小球滤过率。随着肾功能恶化，糖尿病肾病中肾小球通透性的改变似乎与电荷减少有关。在肾小球肾炎中，情况不同，病例之间存在高度变异性。
