HbA(1c) 方法和干扰物的病理咨询。
Pathology consultation on HbA(1c) methods and interferences.
机构信息
Dept of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Hospital Midtown, 550 Peachtree Ave NE, Davis Fischer Bldg, Room 1239, Atlanta, GA 30308;
出版信息
Am J Clin Pathol. 2014 Jan;141(1):5-16. doi: 10.1309/AJCPQ23GTTMLAEVL.
OBJECTIVES
To review the various hemoglobin (Hb) A1c methods, with a focus on interferences resulting from Hb variants.
METHODS
HbA1c is a marker used for the diagnosis and management of diabetes. Each available HbA1c method has advantages and challenges, such as its susceptibility to interferences.
RESULTS
The presence of Hb variants and/or abnormalities in RBC turnover cannot only interfere analytically with HbA1c measurements but also may affect the clinical interpretation of HbA1c values.
CONCLUSIONS
Familiarity with the advantages and challenges of the various methods used for HbA1c testing is essential when establishing therapeutic management and goals based on HbA1c results, especially in populations with a high prevalence of Hb variants.
目的
回顾各种血红蛋白 (Hb) A1c 方法，重点关注 Hb 变异体引起的干扰。
方法
HbA1c 是用于糖尿病诊断和管理的标志物。每种可用的 HbA1c 方法都有其优点和挑战，例如其易受干扰的影响。
结果
Hb 变异体的存在和/或 RBC 周转率异常不仅会干扰 HbA1c 测量的分析结果，还可能影响 HbA1c 值的临床解释。
结论
在根据 HbA1c 结果制定治疗管理和目标时，熟悉 HbA1c 检测中各种方法的优缺点至关重要，尤其是在 Hb 变异体高发人群中。
Zotero 插件