Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital Tainan Branch, Tainan, Taiwan.
J Sex Med. 2014 Jan;11(1):230-9. doi: 10.1111/jsm.12353. Epub 2013 Oct 31.
Obesity has been receiving an increasing amount of attention recently, but investigations regarding the potential impact of obesity, sexual behaviors, and sex hormones on erectile dysfunction (ED) in men have not completely clarified the association.
To identify the relationship between ED, sexual behavior, sexual satisfaction, sex hormones, and obesity in older adult males in Taiwan.
Data were obtained from a baseline survey of 476 older adult males (≧40 years old). Their demographic data, body mass index (BMI), sex hormones, sexual desire, sexual satisfaction, and ED status were assessed.
The International Index of Erectile Function-5 (IIEF-5), Sexual Desire Inventory (SDI), and Sexual Satisfaction Scale (SSS) were used to assess ED, sexual desire, and sexual satisfaction.
In all, 476 men were available for analysis. The mean age of the sample was 51.34 ± 7.84 years (range 40 to 70 years). The IIEF total score had a mean of 19.44 ± 4.98; 264 (55.5%) subjects had ED, 250 (52.9%) were currently obese (BMI ≧27), and 297 (62.4%) had metabolic syndrome. The results showed an increased risk of ED among obese men and subjects with lower levels of sex hormones and lower sexual desire. Testosterone levels were lower in subjects with obesity (P < 0.001). Among the predictors of ED, obesity (odds ratio [OR] = 1.62, 95% CI = 1.07-2.44, P = 0.021), abnormal high sensitivity C-reactive protein (hs-CRP) (OR = 10.59, 95% CI = 4.70-23.87, P < 0.001), and lower serum full testosterone (OR = 3.27, 95% CI = 2.16-4.93, P < 0.001) were significantly independent factors.
This study supports the idea of a close relationship between low levels of sex hormones, sexual desire, sexual satisfaction, obesity, and ED, and also shows that low free testosterone and hs-CRP may predict ED, even in obese populations.
肥胖问题近来受到了越来越多的关注，但有关肥胖、性行为和性激素对男性勃起功能障碍（ED）潜在影响的研究尚未完全阐明两者之间的关联。
在台湾的老年男性中，确定 ED、性行为、性满意度、性激素和肥胖之间的关系。
数据来自 476 名老年男性（≧40 岁）的基线调查。评估了他们的人口统计学数据、体重指数（BMI）、性激素、性欲、性满意度和 ED 状况。
国际勃起功能指数-5（IIEF-5）、性欲量表（SDI）和性满意度量表（SSS）用于评估 ED、性欲和性满意度。
共有 476 名男性可用于分析。样本的平均年龄为 51.34±7.84 岁（40 至 70 岁）。IIEF 总分为 19.44±4.98；264 名（55.5%）受试者存在 ED，250 名（52.9%）为当前肥胖（BMI≧27），297 名（62.4%）患有代谢综合征。结果显示，肥胖男性、性激素水平较低和性欲较低的男性发生 ED 的风险增加。肥胖者的睾丸激素水平较低（P<0.001）。在 ED 的预测因素中，肥胖（优势比[OR] = 1.62，95%置信区间[CI] = 1.07-2.44，P = 0.021）、异常高敏 C 反应蛋白（hs-CRP）（OR = 10.59，95%CI = 4.70-23.87，P<0.001）和较低的血清全睾酮（OR = 3.27，95%CI = 2.16-4.93，P<0.001）是显著的独立因素。
本研究支持低性激素水平、性欲、性满意度、肥胖和 ED 之间密切关系的观点，还表明低游离睾酮和 hs-CRP 可能预测 ED，即使在肥胖人群中也是如此。
