Khan Safdar A, McLean Mary Kay, Slater Margaret R
ASPCA Animal Poison Control Center, 1717 S Philo Rd, Ste 36, Urbana, IL 61802.
J Am Vet Med Assoc. 2014 Jan 1;244(1):95-9. doi: 10.2460/javma.244.1.95.
To determine the frequency, types, and severity of clinical signs; geographic distribution; and treatment information associated with toxicosis caused by 100% tea tree oil (TTO) in dogs and cats in the United States and Canada.
Retrospective case series.
337 dogs and 106 cats with evidence of exposure to 100% TTO.
10-year incident data were retrieved from the ASPCA Animal Poison Control Center database from January 2002 to December 2012. Only evidenced or witnessed incidents assessed as toxicosis or suspected toxicosis were included. Signalment, amount of TTO used, intention of use, and outcome information were evaluated. Severity of illness and correlations with breed, sex, age, and weight were determined.
TTO was intentionally used in 395 of 443 (89%) animals. The amount used ranged from 0.1 to 85 mL. Incidents were reported from 41 states, the District of Columbia, and 4 Canadian provinces. Exposure route was cutaneous in 221 (50%) animals, cutaneous and oral in 133 (30%), and oral in 67 (15%). Clinical signs developed within 2 to 12 hours and lasted up to 72 hours. The most common signs were increased salivation or drooling, signs of CNS depression or lethargy, paresis, ataxia, and tremors. A significant association with severity of illness was found for age and weight, with higher prevalence of major illness in younger and smaller cats.
Intentional or accidental use of 100% TTO in dogs or cats caused serious signs of CNS depression, paresis, ataxia, or tremors within hours after exposure and lasting up to 3 days. Younger cats and those with lighter body weight were at greater risk of developing major illness.
确定美国和加拿大犬猫因100%茶树油（TTO）中毒所致临床症状的发生频率、类型及严重程度；地理分布；以及治疗信息。
回顾性病例系列研究。
337只犬和106只猫，有接触100%TTO的证据。
从美国防止虐待动物协会动物中毒控制中心数据库中检索2002年1月至2012年12月的10年发病数据。仅纳入经评估为中毒或疑似中毒的有证据或有目击记录的事件。评估动物的品种、年龄、性别、体重、TTO使用量、使用意图及结局信息。确定疾病严重程度及其与品种、性别、年龄和体重的相关性。
443只动物中有395只（89%）是故意使用TTO。使用量从0.1毫升到85毫升不等。事件报告来自美国41个州、哥伦比亚特区和加拿大4个省。221只（占50%）动物的接触途径为皮肤接触，133只（占30%）为皮肤和口服接触，67只（占15%）为口服接触。临床症状在接触后2至12小时内出现，持续长达72小时。最常见的症状是流涎增多或流口水、中枢神经系统抑制或嗜睡、轻瘫、共济失调和震颤。发现年龄和体重与疾病严重程度存在显著关联，年轻和体型较小的猫患重病的比例更高。
犬猫故意或意外使用100%TTO会在接触后数小时内引发严重的中枢神经系统抑制、轻瘫、共济失调或震颤症状，持续长达3天。年轻的猫和体重较轻的猫患重病的风险更高。
