HIV感染中的肺动脉高压：简要综述

Pulmonary arterial hypertension in HIV infection: a concise review.

作者信息

Dai Hai-Long, Zhang Ming, Xiao Zhi-Cheng, Guang Xue-Feng, Yin Xiao-Long

机构信息

Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, PR China; The Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, PR China; Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia.

The Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, PR China.

出版信息

Heart Lung Circ. 2014 Apr;23(4):299-302. doi: 10.1016/j.hlc.2013.10.088. Epub 2013 Oct 31.

DOI:10.1016/j.hlc.2013.10.088

PMID:24345377

Abstract

Pulmonary arterial hypertension (PAH) is an infrequent but nevertheless serious life threatening severe complication of human immunodeficiency virus (HIV) infection. In today's era of antiretroviral therapy (ART), the mortality of HIV patients has greatly reduced due to improved immune function and fewer opportunistic infections. However, these patients have an increased incidence of PAH. In this review, we will mainly discuss HIV-related pulmonary arterial hypertension (HRPH) in terms of the epidemiology, pathogenesis, clinical characteristics and treatment.

摘要

肺动脉高压（PAH）是人类免疫缺陷病毒（HIV）感染罕见但严重的危及生命的并发症。在当今抗逆转录病毒疗法（ART）时代，由于免疫功能改善和机会性感染减少，HIV患者的死亡率已大幅降低。然而，这些患者的PAH发病率有所增加。在本综述中，我们将主要从流行病学、发病机制及临床特征和治疗方面讨论HIV相关肺动脉高压（HRPH）。