日常使用，尤其是高 potency 大麻，会促使大麻使用者更早出现精神病症状。 （注：“potency”常见释义为“效力；效能” ，这里结合语境可能指大麻的某种强度等特性，具体准确含义需结合更多背景知识确定 ）
Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.
作者信息
Di Forti Marta, Sallis Hannah, Allegri Fabio, Trotta Antonella, Ferraro Laura, Stilo Simona A, Marconi Arianna, La Cascia Caterina, Reis Marques Tiago, Pariante Carmine, Dazzan Paola, Mondelli Valeria, Paparelli Alessandra, Kolliakou Anna, Prata Diana, Gaughran Fiona, David Anthony S, Morgan Craig, Stahl Daniel, Khondoker Mizanur, MacCabe James H, Murray Robin M
机构信息
Department of Psychosis Studies, Institute of Psychiatry, Kings College London, London, UK;
School of Social and Community Medicine, Bristol University, Bristol, UK;
出版信息
Schizophr Bull. 2014 Nov;40(6):1509-17. doi: 10.1093/schbul/sbt181. Epub 2013 Dec 17.
UNLABELLED
Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated.
METHODS
We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP.
RESULTS
Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11-1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06-1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users.
CONCLUSIONS
Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.
未标记
使用大麻与精神病发病年龄提前（AOP）有关。然而，其原因仍存在争议。
方法
我们对410例首发精神病患者应用Cox比例风险模型，以研究性别、大麻使用模式与AOP之间的关联。
结果
有大麻使用史的患者首次出现精神病发作的年龄（平均年龄=28.2岁，标准差=8.0；中位数年龄=27.1岁）比从未使用过大麻的患者（平均年龄=31.4岁，标准差=9.9；中位数年龄=30.0岁；风险比[HR]=1.42；95%置信区间：1.16 - 1.74；P <.001）更小。在控制性别后，这种关联仍然显著（HR = 1.39；95%置信区间：1.11 - 1.68；P <.001）。15岁及以下开始使用大麻的患者比15岁以后开始使用的患者精神病发病更早（平均年龄=27.0岁，标准差=6.2；中位数年龄=26.9岁）（平均年龄=29.1岁，标准差=8.5；中位数年龄=27.8岁；HR = 1.40；95%置信区间：1.06 - 1.84；P =.050）。重要的是，在所有测试组中，每天使用高效力大麻（臭鼬型）的受试者发病最早（平均年龄=25.2岁，标准差=6.3；中位数年龄=24.6岁），与从未使用者相比（HR = 1.99；95%置信区间：1.50 - 2.65；P <.0001）；这些每天使用高效力大麻的使用者发病平均比不使用大麻的人早6年。
结论
每天使用大麻，尤其是高效力大麻，会促使大麻使用者精神病发病更早。
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