Weaver Jamie R, Bartolomei Marisa S
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, 9-123 Smilow Center for Translational Research, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, 9-123 Smilow Center for Translational Research, Philadelphia, PA 19104, USA.
Biochim Biophys Acta. 2014 Mar;1839(3):169-77. doi: 10.1016/j.bbagrm.2013.12.002. Epub 2013 Dec 15.
Genomic imprinting is an epigenetic phenomenon in which genes are expressed monoallelically in a parent-of-origin-specific manner. Each chromosome is imprinted with its parental identity. Here we will discuss the nature of this imprinting mark. DNA methylation has a well-established central role in imprinting, and the details of DNA methylation dynamics and the mechanisms that target it to imprinted loci are areas of active investigation. However, there is increasing evidence that DNA methylation is not solely responsible for imprinted expression. At the same time, there is growing appreciation for the contributions of post-translational histone modifications to the regulation of imprinting. The integration of our understanding of these two mechanisms is an important goal for the future of the imprinting field. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
基因组印记是一种表观遗传现象，其中基因以亲本来源特异性的方式单等位基因表达。每条染色体都被印记上其亲本身份。在此，我们将讨论这种印记标记的性质。DNA甲基化在印记中具有公认的核心作用，DNA甲基化动态变化的细节以及将其靶向印记位点的机制是当前积极研究的领域。然而，越来越多的证据表明，DNA甲基化并非印记表达的唯一原因。与此同时，人们越来越认识到翻译后组蛋白修饰对印记调控的贡献。整合我们对这两种机制的理解是印记领域未来的一个重要目标。本文是名为“动物发育的染色质和表观遗传调控”的特刊的一部分。
