Celal Bayar University, Medical School, Department of Clinical Biochemistry, Manisa, Turkey.
Celal Bayar University, Medical School, Department of Clinical Biochemistry, Manisa, Turkey.
Obes Res Clin Pract. 2010 Jan-Mar;4(1):e1-e82. doi: 10.1016/j.orcp.2009.06.003.
Aims of this study were to compare serum leptin levels, atherosclerotic markers and carotid intima media thickness (IMT) among the overweight, obese and normal weight healthy adolescents and to investigate the association of carotid IMT with leptin and atherosclerotic markers in adolescence.
Seventy obese-overweight adolescents (27 of them obese, 43 of them overweight) and 72 two normal weight adolescents aged 14-18 years were included in this study. Leptin and homocysteine levels and lipid profiles were determined and carotid IMT were measured in all adolescents. Subjects were evaluated as obese-overweight and normal weight and obese, overweight and normal weight.
Carotid IMT was significantly different among the overweight adolescents, obese adolescents and the control group (p < 0.001). Leptin levels were significantly higher in obese-overweight adolescents compared to the control group (p < 0.001). Apolipoprotein (Apo) B levels were significantly higher in obese adolescents than the overweight ones and the control group (p < 0.016). There were significantly positive correlations of carotid IMT with leptin, homocysteine and Apo B levels (p < 0.05, r = 0.33, 0.28, 021, respectively). The factors associated with carotid IMT were leptin and ApoB levels (β = 0.632, p < 0.04, β = 0.264, p = 0.019, respectively).
Subclinical atherosclerosis determined by carotid IMT begins in overweight adolescents. Elevated leptin and Apo B levels are independent predictors of subclinical atherosclerosis. Leptin resistance, which is related to subclinical atherosclerosis, also begins in overweight adolescents. High Apo B levels, which promote development of atherosclerosis are more prominent in obese adolescents than other groups. For these reasons, all necessary precautions should be taken in overweight adolescents to prevent atherosclerosis as well as in obese adolescents.
本研究旨在比较超重、肥胖和正常体重健康青少年的血清瘦素水平、动脉粥样硬化标志物和颈动脉内膜中层厚度（IMT），并探讨青少年颈动脉 IMT 与瘦素和动脉粥样硬化标志物的关系。
本研究纳入了 70 名超重/肥胖青少年（其中 27 名肥胖，43 名超重）和 72 名正常体重青少年，年龄在 14-18 岁之间。所有青少年均测定了瘦素和同型半胱氨酸水平及血脂谱，并测量了颈动脉 IMT。将受试者分为超重/肥胖组和正常体重组，以及肥胖组、超重组和正常体重组。
超重青少年、肥胖青少年和对照组的颈动脉 IMT 差异有统计学意义（p < 0.001）。与对照组相比，超重/肥胖青少年的瘦素水平显著升高（p < 0.001）。与超重青少年和对照组相比，肥胖青少年的载脂蛋白（Apo）B 水平显著升高（p < 0.016）。颈动脉 IMT 与瘦素、同型半胱氨酸和 Apo B 水平呈显著正相关（p < 0.05，r = 0.33、0.28 和 0.21）。与颈动脉 IMT 相关的因素是瘦素和 ApoB 水平（β = 0.632，p < 0.04，β = 0.264，p = 0.019）。
颈动脉 IMT 确定的亚临床动脉粥样硬化始于超重青少年。升高的瘦素和 Apo B 水平是亚临床动脉粥样硬化的独立预测因子。与亚临床动脉粥样硬化相关的瘦素抵抗也始于超重青少年。与其他组相比，肥胖青少年的高 Apo B 水平（促进动脉粥样硬化的发展）更为明显。因此，超重青少年应采取一切必要的预防措施来预防动脉粥样硬化，肥胖青少年也应采取一切必要的预防措施来预防动脉粥样硬化。
