Okur Ilyas, Tumer Leyla, Ezgu Fatih Suheyl, Yesilkaya Ediz, Aral Arzu, Oktar Suna Ozhan, Bideci Aysun, Hasanoglu Alev
J Pediatr Endocrinol Metab. 2013;26(7-8):657-62. doi: 10.1515/jpem-2012-0374.
Children with obesity have a high cardiovascular risk and an impaired oxidant-antioxidant status, which may lead to endothelial dysfunction and increased carotid intima media thickness (IMT) even in childhood. The aim of this study was to investigate the circulating oxidized low-density lipoprotein (LDL) concentrations and the IMT of carotid arteries in prepubertal obese children, and also to search for its possible association with carotid atherosclerosis.
Twenty-seven prepubertal obese children (age, 7.48±2.05 years; boys, 59%) and 30 healthy children (age, 7.80±2.19 years; boys, 55%) were included in the study. Serum concentrations of oxidized LDL, total cholesterol, triglyceride, high-density lipoprotein, LDL, and glucose were measured, and carotid IMT was determined by ultrasound.
Serum oxidized LDL levels were significantly higher in prepubertal obese children than in healthy children (p<0.01). No significant correlation was observed between oxidized LDL levels and carotid IMT measurements. However, a significant positive correlation was found between oxidized LDL levels and body mass index, total cholesterol, and LDL-cholesterol.
Our findings revealed that the oxidation of LDL starts early in obese children but the carotid IMT is not significantly affected. Also, oxidized LDL levels are more strongly associated with obesity and dyslipidemia than the carotid IMT in prepubertal children.
肥胖儿童具有较高的心血管风险以及氧化-抗氧化状态受损，这可能导致内皮功能障碍，并使颈动脉内膜中层厚度（IMT）增加，甚至在儿童期就会出现这种情况。本研究的目的是调查青春期前肥胖儿童循环氧化低密度脂蛋白（LDL）浓度和颈动脉IMT，并寻找其与颈动脉粥样硬化的可能关联。
本研究纳入了27名青春期前肥胖儿童（年龄7.48±2.05岁；男孩占59%）和30名健康儿童（年龄7.80±2.19岁；男孩占55%）。测量血清中氧化LDL、总胆固醇、甘油三酯、高密度脂蛋白、LDL和葡萄糖的浓度，并通过超声测定颈动脉IMT。
青春期前肥胖儿童的血清氧化LDL水平显著高于健康儿童（p<0.01）。氧化LDL水平与颈动脉IMT测量值之间未观察到显著相关性。然而，氧化LDL水平与体重指数、总胆固醇和LDL胆固醇之间存在显著正相关。
我们的研究结果表明，肥胖儿童中LDL的氧化在早期就已开始，但颈动脉IMT未受到显著影响。此外，在青春期前儿童中，氧化LDL水平与肥胖和血脂异常的相关性比与颈动脉IMT的相关性更强。
