稳定的环氧化脂肪酸可调节炎症、疼痛、血管生成和癌症。
Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer.
机构信息
Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, United States; Department of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, United States.
出版信息
Prog Lipid Res. 2014 Jan;53:108-23. doi: 10.1016/j.plipres.2013.11.003. Epub 2013 Dec 15.
Abstract
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450 epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to regulate various biological processes including inflammation, pain and angiogenesis. The EpFAs are further metabolized by soluble epoxide hydrolase (sEH) to form fatty acid diols which are usually less-active. Pharmacological inhibitors of sEH that stabilize endogenous EpFAs are being considered for human clinical uses. Here we review the biology of ω-3 and ω-6 EpFAs on inflammation, pain, angiogenesis and tumorigenesis.
摘要
环氧脂肪酸（EpFAs）是由多不饱和脂肪酸的细胞色素 P450 加氧酶产生的脂类介质，是调节炎症、疼痛和血管生成等各种生物学过程的重要信号分子。EpFAs 进一步被可溶性环氧化物水解酶（sEH）代谢形成脂肪酸二醇，其通常活性较低。正在考虑使用 sEH 的药理学抑制剂来稳定内源性 EpFAs，以用于人类临床应用。本文综述了 ω-3 和 ω-6 EpFAs 在炎症、疼痛、血管生成和肿瘤发生中的生物学作用。
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