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Periodontal inflammation potentially inhibits hepatic cytochrome P450 expression and disrupts the omega-3 epoxidation pathway in a murine model.

作者信息

Daidouji Yoshino, Suzuki Shigeki, Wang Xiuting, Fahreza Rahmad Rifqi, Nemoto Eiji, Yamada Satoru

机构信息

Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.

出版信息

J Dent Sci. 2025 Jan;20(1):444-451. doi: 10.1016/j.jds.2024.05.028. Epub 2024 May 29.

DOI:10.1016/j.jds.2024.05.028
PMID:39873042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11763211/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/60d9499e61f1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/b020e58e7427/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/2c8798dea676/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/a59cac342d44/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/60d9499e61f1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/b020e58e7427/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/2c8798dea676/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/a59cac342d44/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c6c/11763211/60d9499e61f1/gr4.jpg

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1
Periodontal inflammation potentially inhibits hepatic cytochrome P450 expression and disrupts the omega-3 epoxidation pathway in a murine model.在小鼠模型中，牙周炎症可能会抑制肝细胞色素P450的表达，并破坏ω-3环氧化途径。
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2
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本文引用的文献

1
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.牙周膜成纤维细胞利用类异戊二烯中间体法呢基二磷酸来维持骨/牙骨质生成分化能力。
J Dent Sci. 2025 Jan;20(1):560-568. doi: 10.1016/j.jds.2024.04.025. Epub 2024 May 3.
2
Dynamic changes in chromatin accessibility during the differentiation of dental pulp stem cells reveal that induction of odontogenic gene expression is linked with specific enhancer construction.牙髓干细胞分化过程中染色质可及性的动态变化表明，牙源性基因表达的诱导与特定增强子构建有关。
J Dent Sci. 2024 Jul;19(3):1705-1713. doi: 10.1016/j.jds.2023.10.022. Epub 2023 Nov 26.
3
The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression.
组蛋白去乙酰化酶抑制剂MS-275通过诱导纤连蛋白表达增强牙髓干细胞的基质矿化。
J Dent Sci. 2024 Jul;19(3):1680-1690. doi: 10.1016/j.jds.2023.11.019. Epub 2023 Dec 3.
4
Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases.糖尿病与牙周/牙髓根尖周疾病之间的相互作用。
J Dent Sci. 2024 Jul;19(3):1338-1347. doi: 10.1016/j.jds.2024.03.021. Epub 2024 Apr 5.
5
Procyanidin B2 enhances anti-inflammatory responses of periodontal ligament cells by inhibiting the dominant negative pro-inflammatory isoforms of peroxisome proliferator-activated receptor γ.原花青素B2通过抑制过氧化物酶体增殖物激活受体γ的显性负性促炎亚型来增强牙周膜细胞的抗炎反应。
J Dent Sci. 2024 Jul;19(3):1801-1810. doi: 10.1016/j.jds.2023.09.027. Epub 2023 Oct 6.
6
The role of microbiome in the pathogenesis of oral-gut-liver axis between periodontitis and nonalcoholic fatty liver disease.微生物群落在牙周炎与非酒精性脂肪性肝病之间的口腔-肠道-肝脏轴发病机制中的作用。
J Dent Sci. 2023 Jul;18(3):972-975. doi: 10.1016/j.jds.2023.03.012. Epub 2023 Mar 25.
7
Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model.靶向 LATS1/2 激活 YAP/TAZ 可增强小鼠牙周组织再生。
Int J Mol Sci. 2023 Jan 4;24(2):970. doi: 10.3390/ijms24020970.
8
Association of periodontitis and oral microbiomes with Alzheimer's disease: A narrative systematic review.牙周炎和口腔微生物群与阿尔茨海默病的关联：一项叙述性系统综述。
J Dent Sci. 2022 Oct;17(4):1762-1779. doi: 10.1016/j.jds.2022.07.001. Epub 2022 Jul 21.
9
Linoleic acid and linoleate diols in neonatal cord blood influence birth weight.新生儿脐血中的亚油酸和亚油酸二醇影响出生体重。
Front Endocrinol (Lausanne). 2022 Aug 25;13:986650. doi: 10.3389/fendo.2022.986650. eCollection 2022.
10
Periodontal Inflammation and Systemic Diseases: An Overview.牙周炎与全身疾病：概述
Front Physiol. 2021 Oct 27;12:709438. doi: 10.3389/fphys.2021.709438. eCollection 2021.