Elabiad Mohamad T, Christensen Michael
Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee.
Am J Perinatol. 2014 Nov;31(10):863-8. doi: 10.1055/s-0033-1361936. Epub 2013 Dec 17.
To describe the blood level changes of mercury and lead after packed red blood cell (PRBC) transfusions in ≤ 750 g birth weight infants.
Heavy metal blood levels were measured in infants in PRBC units on 1st, 4th, 5th, and 7th days (D1, D4, D5, and D7) of life and in urine on D1, D4, and D7.
A total of 10 infants were enrolled with a mean birth weight of 632 ± 72 g. Out of which nine infants received one or more PRBC transfusions, with an average of 2.9 ± 2.5 transfusions per infant. Heavy metals were detected in all the transfusions. The average mercury level was 1.33 µg/L on D1 and 1.66 µg/L on D7, p > 0.05. The average lead level was 0.32 µg/dL on D1 and 0.56 µg/dL on D7, p > 0.05. Urinary mercury excretion increased in infants with no bowel movements. Urinary excretion of lead decreased over time as blood levels increased.
After receiving blood transfusions, the blood levels of mercury and lead were maintained at the end of the 1st week of life. As there is no evidence of a proportionate increase in excretory amounts of these heavy metals, there is a concern that they are retained and potentially exert toxic effects.
描述出生体重≤750g的婴儿输注浓缩红细胞（PRBC）后血液中汞和铅水平的变化。
在出生第1天、第4天、第5天和第7天（D1、D4、D5和D7）测量婴儿PRBC单位中的重金属血液水平，并在D1、D4和D7测量尿液中的重金属水平。
共纳入10名婴儿，平均出生体重为632±72g。其中9名婴儿接受了一次或多次PRBC输注，每名婴儿平均输注2.9±2.5次。在所有输注中均检测到重金属。D1时平均汞水平为1.33µg/L，D7时为1.66µg/L，p>0.05。D1时平均铅水平为0.32µg/dL，D7时为0.56µg/dL，p>0.05。无排便的婴儿尿汞排泄增加。随着血液中铅水平的升高，尿铅排泄量随时间减少。
输血后，出生后第1周结束时血液中的汞和铅水平保持稳定。由于没有证据表明这些重金属的排泄量成比例增加，因此担心它们会在体内蓄积并可能产生毒性作用。
