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多瘤病毒中T抗原下调细胞间连接通讯。

Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.

作者信息

Azarnia R, Loewenstein W R

出版信息

Mol Cell Biol. 1987 Feb;7(2):946-50. doi: 10.1128/mcb.7.2.946-950.1987.

DOI:10.1128/mcb.7.2.946-950.1987
PMID:2434836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365156/
Abstract

We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.

摘要

我们研究了多瘤病毒中T抗原对转染了可诱导性中T重组DNA的大鼠F细胞或感染了条件性突变病毒的大鼠F细胞间细胞通讯的影响。当中T转录被诱导时或中T转变为转化+形式时，连接通透性（可逆地）下降。该效应与蛋白酪氨酸激酶活性的升高相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a222/365156/d8b92bc6b138/molcellb00074-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a222/365156/d8b92bc6b138/molcellb00074-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a222/365156/d8b92bc6b138/molcellb00074-0391-a.jpg

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Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells.细胞间连接通讯的丧失与乳腺腺癌细胞的转移潜能相关。
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