TSLP：哮喘发病机制的关键调节因子。
TSLP: A Key Regulator of Asthma Pathogenesis.
作者信息
West Erin E, Kashyap Mohit, Leonard Warren J
机构信息
Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.
出版信息
Drug Discov Today Dis Mech. 2012 Dec 1;9(3-4). doi: 10.1016/j.ddmec.2012.09.003.
Abstract
Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4 T cells, and recent work has revealed the impact of TSLP on multiple cell types. Furthermore, TSLP plays an important role in the sequential progression of atopic dermatitis to asthma, clarifying the key role of TSLP in the pathogenesis of asthma, a finding with therapeutic implications.
摘要
哮喘是一种气道的复杂病症，其特征为2型辅助性T（Th2）炎症。多效性细胞因子胸腺基质淋巴细胞生成素（TSLP）已成为参与协调哮喘和其他特应性疾病中所见炎症的重要因子。早期研究阐明了TSLP对CD4 T细胞的作用，最近的研究揭示了TSLP对多种细胞类型的影响。此外，TSLP在特应性皮炎向哮喘的连续进展中起重要作用，这阐明了TSLP在哮喘发病机制中的关键作用，这一发现具有治疗意义。
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TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice.角质形成细胞产生的 TSLP 通过皮肤促进过敏原致敏，并由此引发小鼠的特应性进展。
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