Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Int Arch Allergy Immunol. 2013;160(1):18-26. doi: 10.1159/000341665. Epub 2012 Aug 30.
Thymic stromal lymphopoietin (TSLP), an interleukin 7-like cytokine, can trigger dendritic cell (DC)-mediated T-helper type 2 (Th2) inflammatory responses. Recent evidence demonstrates that cytokines TSLP and OX40 (CD134)/OX40 ligand seem to be important players in the maintenance of Th2 memory pool in the pathogenesis of asthma. Accumulating data reveal that the pathogenic T cells involved in asthma are likely to be inflammatory Th2 cells. TSLP is involved in the development of asthma through crosstalk with nuclear factor NF-ĸB. Progression of skin fibrosis in atopic dermatitis occurs via TSLP/TSLP receptor. TSLP-mediated dermal inflammation aggravates experimental allergic asthma. Also, TSLP polymorphisms are associated with susceptibility to asthma, atopic dermatitis, and eczema herpeticum. These findings suggest a master switch of TSLP in the initiation of allergic and adaptive inflammation through innate pathways at the epithelial cell-DC interface. The TSLP pathway is therefore a promising target for immunotherapy of allergic diseases.
胸腺基质淋巴细胞生成素 (TSLP)，一种白细胞介素 7 样细胞因子，可引发树突状细胞 (DC) 介导的 T 辅助细胞 2 (Th2) 炎症反应。最近的证据表明，细胞因子 TSLP 和 OX40（CD134）/OX40 配体似乎在哮喘发病机制中 Th2 记忆池的维持中发挥重要作用。越来越多的资料显示，参与哮喘的致病 T 细胞可能是炎症性 Th2 细胞。TSLP 通过与核因子 NF-ĸB 的相互作用参与哮喘的发展。特应性皮炎的皮肤纤维化进展通过 TSLP/TSLP 受体发生。TSLP 介导的皮肤炎症加重实验性变应性哮喘。此外，TSLP 多态性与哮喘、特应性皮炎和疱疹样湿疹的易感性有关。这些发现表明 TSLP 是一种主开关，通过上皮细胞-DC 界面的先天途径启动过敏和适应性炎症。因此，TSLP 途径是过敏疾病免疫治疗的一个有希望的靶点。
