Shiramizu M, Hoshino H, Katsuoka Y, Osamura Y
Hinyokika Kiyo. 1986 Dec;32(12):1843-8.
Indirect immunoperoxidase staining was carried out on seminomatous tumors of testes (22 specimens) using anti-placental alkaline phosphatase antibody to search for the usefulness of placental alkaline phosphatase as a tumor marker. All of the seminomas showed positive staining mainly on the cell surface. However, the normal testes and non-seminomas showed negative staining. Of interest, normal tissues outside the tumor mass showed positive staining. This phenomenon is considered to be suggestive of carcinoma in situ. Immunohistochemical study of placental alkaline phosphatase on the seminomas is a useful method for histopathological diagnosis and may be useful for understanding the pathogenesis of the tumor.
使用抗胎盘碱性磷酸酶抗体对睾丸精原细胞瘤（22个标本）进行间接免疫过氧化物酶染色，以探寻胎盘碱性磷酸酶作为肿瘤标志物的效用。所有精原细胞瘤主要在细胞表面呈现阳性染色。然而，正常睾丸和非精原细胞瘤呈现阴性染色。有趣的是，肿瘤块外的正常组织呈现阳性染色。这种现象被认为提示原位癌。对精原细胞瘤进行胎盘碱性磷酸酶的免疫组织化学研究是一种用于组织病理学诊断的有用方法，可能有助于理解肿瘤的发病机制。
