[通过分析克隆检测到的McA-RH 7777肝癌细胞系中的克隆内变异性]
[Intraclonal variability in the McA-RH 7777 hepatoma cell line detected by analytical cloning].
作者信息
Eraĭzer T L, Khamzina L S, Abelev G I
出版信息
Biull Eksp Biol Med. 1987 Mar;103(3):324-7.
PMID:2435337
Abstract
McA-RH 7777 hepatoma cell line has been cloned twice at a week's interval (analytical cloning). Alpha-fetoprotein (AFP) phenotypes of primary and secondary clones from 46 primary clones were analyzed. High interclonal variability exceeded the mutation rate by several orders. The interclonal differences have been also found in the variability rates.
摘要
McA-RH 7777肝癌细胞系每隔一周进行了两次克隆（分析性克隆）。分析了来自46个原代克隆的一代和二代克隆的甲胎蛋白（AFP）表型。克隆间的高变异性比突变率高出几个数量级。在变异性率方面也发现了克隆间差异。
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