Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama-Machi, Oita, Japan.
Neuropsychiatr Dis Treat. 2013;9:1899-905. doi: 10.2147/NDT.S48722. Epub 2013 Dec 6.
Bipolar disorder (BP) is often associated with a change in hypothalamus- pituitary-adrenal axis function change due to chronic stress. Salivary α-amylase (sAA) levels increase in response to psychosocial stress and thus function as a marker of sympathoadrenal medullary system activity. However, sAA has been studied less often than salivary cortisol in BP patients.
We measured Profile of Mood States and State-Trait Anxiety Inventory scores, heart rate variability, and salivary cortisol levels during electrical stimulation stress in 25 BP patients and 22 healthy volunteers.
Tension-anxiety, depression-dejection, anger-hostility, fatigue, and confusion scores in BP patients significantly increased compared with those of the healthy controls. In contrast, the vigor scores of BP patients significantly decreased compared with those of the healthy controls. Significant difference in the sAA levels was observed between BP patients and healthy controls. sAA of female patients was significantly higher than that of female healthy controls, and sAA in male patients tended to be higher than that of male healthy controls. No difference in salivary cortisol was observed between BP patients and the healthy controls. Only three time points were measured before and after the electrical stimulation stress. Furthermore, sAA secretion by BP patients increased before and after electrical stimulation.
These preliminary results suggest that sAA may be a useful biological marker for BP patients.
由于慢性应激，双相情感障碍（BP）常与下丘脑-垂体-肾上腺轴功能变化有关。唾液α-淀粉酶（sAA）水平会因心理社会应激而升高，因此可作为交感肾上腺髓质系统活性的标志物。然而，与 BP 患者的唾液皮质醇相比，sAA 研究得较少。
我们测量了 25 名 BP 患者和 22 名健康志愿者在电刺激应激期间的心境状态量表和状态特质焦虑量表评分、心率变异性和唾液皮质醇水平。
与健康对照组相比，BP 患者的紧张-焦虑、抑郁-沮丧、愤怒-敌意、疲劳和困惑评分显著升高。相反，BP 患者的活力评分显著低于健康对照组。BP 患者和健康对照组之间 sAA 水平存在显著差异。女性患者的 sAA 明显高于女性健康对照组，男性患者的 sAA 倾向于高于男性健康对照组。BP 患者和健康对照组之间的唾液皮质醇无差异。仅在电刺激应激前后测量了三个时间点。此外，BP 患者的 sAA 分泌在电刺激前后增加。
这些初步结果表明，sAA 可能是 BP 患者的一个有用的生物学标志物。
