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婴儿出生后头六个月内特应性皮炎的患病率:作者观察结果

Prevalence of atopic dermatitis in infants during the first six months of life: authors' observations.

作者信息

Kamer Barbara, Pasowska Renata, Dółka Elżbieta, Blomberg Agnieszka, Rotsztejn Helena

机构信息

Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. Head of Department: Prof. Przemysław Oszukowski MD, PhD ; 2 Department of Paediatrics and Allergology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. Head of Department: Prof. Barbara Kamer MD, PhD.

2 Department of Paediatrics and Allergology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. Head of Department: Prof. Barbara Kamer MD, PhD.

出版信息

Postepy Dermatol Alergol. 2013 Oct;30(5):277-81. doi: 10.5114/pdia.2013.38355. Epub 2013 Oct 30.

Abstract

INTRODUCTION

Atopic dermatitis (AD) is a frequent chronic skin disease in infants. It creates great difficulties, both diagnostic and therapeutic.

AIM

To assess the prevalence of atopic dermatitis in infants during the first 6 months of life.

MATERIAL AND METHODS

The analysis comprised 2256 children at the age of not more than 6 months, treated at the 2(nd) Department of Paediatrics and Allergology of the Polish Mother's Memorial Hospital in Lodz, Poland, during seven years. Out of all the patients, children with cutaneous changes were isolated, and the location, type and aetiology of changes were assessed.

RESULTS

Dermal changes were diagnosed in 471 children, including 391 (17.3% of all the patients) with atopic dermatitis. Out of the children with AD, IgE-dependent allergy was identified in 39.9%. Cow's milk protein was the most frequent sensitising allergen. In 71.6% of the infants, cutaneous changes were disseminated and involved at least two areas of the body. All of them were strongly itching. An applied elimination diet, together with anti-allergic medications in some of the children, provided a clear clinical improvement.

CONCLUSIONS

Performed studies demonstrated the prevalence of atopic dermatitis in 17.3% of examined children. The changes in children with AD were disseminated, what was confirmed already at the infantile age. The obtained clinical improvement after the applied therapy indicates a relationship between the observed symptoms and allergic disease.

摘要

引言

特应性皮炎(AD)是婴儿常见的慢性皮肤病。它在诊断和治疗方面都带来了很大困难。

目的

评估6个月以内婴儿特应性皮炎的患病率。

材料与方法

分析了波兰罗兹市波兰母亲纪念医院儿科与过敏科第二科室七年间收治的2256名6个月及以下儿童。在所有患者中,分离出有皮肤改变的儿童,并评估改变的部位、类型和病因。

结果

471名儿童被诊断有皮肤改变,其中391名(占所有患者的17.3%)患有特应性皮炎。在患有特应性皮炎的儿童中,39.9%被确定为IgE依赖型过敏。牛奶蛋白是最常见的致敏过敏原。71.6%的婴儿皮肤改变呈播散性,累及身体至少两个部位。所有患儿均有强烈瘙痒。采用的排除饮食法,以及部分儿童使用抗过敏药物后,临床症状明显改善。

结论

所进行的研究表明,17.3%的受检儿童患有特应性皮炎。特应性皮炎患儿的皮肤改变呈播散性,这在婴儿期就已得到证实。应用治疗后获得的临床改善表明所观察到的症状与过敏性疾病之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aca/3858654/bfabf5b493fa/PDIA-30-21575-g001.jpg

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