血清胆固醇、LDL 和 HDL 水平对胆石胆固醇浓度的影响。
The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration.
机构信息
S. Selcuk Atamanalp, Professor, Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
M. Sait Keles, Professor, Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
出版信息
Pak J Med Sci. 2013 Jan;29(1):187-90. doi: 10.12669/pjms.291.2798.
OBJECTIVE
Gallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration.
METHODOLOGY
The gallstones of 75 patients with cholelithiasis were examined using spectrophotometry.
RESULTS
High serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05).
CONCLUSION
The relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.
目的
胆囊结石在西方世界较为常见，其中 70%至 80%的胆囊结石为胆固醇结石。本研究旨在探讨血清胆固醇、LDL 和 HDL 水平对胆囊胆固醇结石胆固醇浓度的影响。
方法
通过分光光度法检测 75 例胆石症患者的胆囊结石。
结果
高血清胆固醇和 LDL 水平与高胆固醇结石发生率相关（86.7%比 40.0%，P<0.001；75.0%比 48.9%，P<0.05）。同样，高血清胆固醇和 LDL 水平与高胆囊结石胆固醇浓度相关（63.6%比 44.4%，P<0.001；62.3%比 46.0%，P<0.001）。相反，低血清 HDL 水平似乎不会影响胆囊胆固醇结石的发生（分别为 60.0%比 58.3%，P>0.05）或胆囊结石胆固醇浓度（分别为 50.8%比 52.4%，P>0.05）。
结论
胆固醇、LDL 和 HDL 水平与胆固醇性胆囊结石形成之间的关系是多因素和复杂的，还取决于其他个体特征。
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