Yang Shuang, Song Jianhui, Yang Zhengbo, Li Nanbo, Wu Ju, Hou Shuangshuang
Department of Operating room, Fuyang Normal University Affiliated Second Hospital, Fuyang 236000, Anhui, China.
Department of General Surgery, Affiliated Xinhua Hospital of Dalian University, Dalian 116001, Liaoning, China.
Prev Med Rep. 2025 Jan 13;50:102972. doi: 10.1016/j.pmedr.2025.102972. eCollection 2025 Feb.
Although substantial evidence suggests an association between dyslipidemia as an isolated factor and gallstones, research on the Atherogenic Index of Plasma (AIP) and gallstones remains limited.
A total of 3557 eligible adults from the United States were selected for cross-sectional analysis using the 2017-2020 National Health and Nutrition Examination Survey database. Logistic regression was employed to evaluate the association between AIP gallstones. Restricted cubic spline (RCS) analysis and threshold effect analysis were conducted to explore potential non-linear relationship.
The study found a positive association between higher AIP levels and higher odds of gallstones. In the fully adjusted logistic regression model, each 1-unit increase in AIP was associated with 59 % higher odds of gallstones (OR = 1.59, 95 % CI: 1.06, 2.38). Compared to the lowest quartile of AIP, the highest quartile showed 82 % higher odds of gallstones (OR = 1.82, 95 % CI: 1.23, 2.69). RCS analysis revealed a non-linear relationship between AIP and gallstones, with threshold effect analysis identifying a turning point at -0.13, where AIP had a positive correlation with gallstones before this threshold.
Higher AIP is positively correlated with higher odds of gallstones, showing a non-linear relationship. As AIP increases, the odds of gallstones also rise, but this relationship is no longer observed beyond a certain threshold. It is recommended to maintain appropriate AIP levels to reduce the incidence of gallstones.
尽管大量证据表明血脂异常作为一个独立因素与胆结石之间存在关联，但关于血浆致动脉粥样硬化指数（AIP）与胆结石的研究仍然有限。
使用2017 - 2020年美国国家健康与营养检查调查数据库，选取了3557名符合条件的美国成年人进行横断面分析。采用逻辑回归评估AIP与胆结石之间的关联。进行受限立方样条（RCS）分析和阈值效应分析以探索潜在的非线性关系。
研究发现较高的AIP水平与较高的胆结石发病几率呈正相关。在完全调整的逻辑回归模型中，AIP每增加1个单位，胆结石发病几率增加59%（OR = 1.59，95% CI：1.06，2.38）。与AIP最低四分位数相比，最高四分位数的胆结石发病几率高82%（OR = 1.82，95% CI：1.23，2.69）。RCS分析揭示了AIP与胆结石之间的非线性关系，阈值效应分析确定转折点为-0.13，在此阈值之前AIP与胆结石呈正相关。
较高的AIP与较高的胆结石发病几率呈正相关，呈现非线性关系。随着AIP升高，胆结石发病几率也上升，但超过一定阈值后这种关系不再存在。建议维持适当的AIP水平以降低胆结石的发生率。
