慢性丙型肝炎非糖尿病患者的胰岛素抵抗。
Insulin resistance in non-diabetic patients of chronic Hepatitis C.
机构信息
Dr. Zareen Kiran, MBBS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Dr. Bader Faiyaz Zuberi, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
出版信息
Pak J Med Sci. 2013 Jan;29(1):201-4. doi: 10.12669/pjms.291.2888.
OBJECTIVE
To determine insulin resistance in non-diabetic chronic hepatitis C patients using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).
METHODOLOGY
Patients having anti-HCV positive were included in this study. Patients with diabetes mellitus, thyroid disease, hyperlipidemias, hypercortisolism and infective diseases other than hepatitis C were excluded. Age, weight, height and absence of diabetes were documented. Fasting blood glucose and fasting insulin levels were done. Body mass index and insulin resistance was calculated using the formulas. Patients having insulin resistance using formula HOMA-IR>2.5 were labeled as insulin resistant. Data was analyzed using SPSS-18.
RESULTS
One hundred and fifty five patients according to sample size estimation were enrolled, in whom HOMA-IR was calculated, the mean value was found to be 2.47 ±1.30. A total of 79 (51%) of patients had HOMA-IR more than 2.5 showing insulin resistance.
CONCLUSION
In a third world country like Pakistan, where there is a high prevalence of hepatitis C infection, the consequences of the disease are also very common. Insulin resistance was found in 51% of patients with chronic hepatitis C.
目的
使用稳态模型评估胰岛素抵抗（HOMA-IR）来确定非糖尿病慢性丙型肝炎患者的胰岛素抵抗情况。
方法
本研究纳入了抗 HCV 阳性的患者。排除了患有糖尿病、甲状腺疾病、高脂血症、皮质醇增多症和除丙型肝炎以外的传染病的患者。记录了年龄、体重、身高和无糖尿病情况。检测了空腹血糖和空腹胰岛素水平。使用公式计算体重指数和胰岛素抵抗。使用公式 HOMA-IR＞2.5 的患者被标记为胰岛素抵抗。使用 SPSS-18 对数据进行分析。
结果
根据样本量估计，共纳入 155 名患者，计算了他们的 HOMA-IR，平均值为 2.47±1.30。共有 79 名（51%）患者的 HOMA-IR 超过 2.5，显示出胰岛素抵抗。
结论
在像巴基斯坦这样的第三世界国家，丙型肝炎感染的患病率很高，这种疾病的后果也很常见。在慢性丙型肝炎患者中，有 51%的患者存在胰岛素抵抗。
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