Hui-Yu Chang, MD, Department of Otolaryngology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Hua Jiang, MD, PhD, Department of Otolaryngology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Pak J Med Sci. 2013 Jan;29(1):218-9. doi: 10.12669/pjms.291.2490.
Multiple primary malignancies are not rare. While metachronous triple cancers are rare and a triple tumor case involving maxillary sinus and tympanic membrane is exceptionally rare. We present such an extremely rare case with the index tumor of adenoid cystic carcinoma of the maxillary sinus and 14 years later esophageal cancer was observed as a metachronous tumor. One year after esophageal cancer, squamous cell carcinoma arising from tympanic membrane was detected. Before the tumor of tympanic membrane was observed, the patient had received total three radiation courses. Prior radiation therapy is suspected to be playing a role in inducing the squamous cell carcinoma of the tympanic membrane.
多原发恶性肿瘤并不罕见。虽然同时性三原发癌较为罕见，而涉及上颌窦和鼓膜的三发性肿瘤则极为罕见。我们报告了这样一个极其罕见的病例，其主瘤为上颌窦腺样囊性癌，14 年后观察到食管癌为同时性肿瘤。食管癌 1 年后，检测到源于鼓膜的鳞状细胞癌。在观察到鼓膜肿瘤之前，患者已接受了总共 3 次放疗。怀疑先前的放射治疗在诱导鼓膜的鳞状细胞癌中发挥了作用。
