外耳道鳞状细胞癌。
Squamous cell carcinoma of the external auditory canal.
作者信息
Lobo David, Llorente José L, Suárez Carlos
机构信息
Department of Otorhinolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
出版信息
Skull Base. 2008 May;18(3):167-72. doi: 10.1055/s-2007-994290.
OBJECTIVES
This study aims to analyze the treatments, prognostic variables, and outcomes of patients with squamous cell carcinomas (SCC) of the external auditory canal (EAC) and middle ear treated in our department over a 15-year period.
DESIGN
A retrospective analysis of 19 patients treated in our department between 1990 and 2006. The patients were staged according to the Pittsburgh classification. Patients were treated with either a lateral (LTBR) or an extended temporal bone resection (total or subtotal). Parotidectomy was performed in patients with suspected clinical or radiological invasion and postoperative radiotherapy was the adjuvant treatment in most patients in advanced stages.
RESULTS
The overall 5-year survival was 37%. There were no patients in stage I. The survival rates were 100%, 25%, and 16% for stages II, III, and IV, respectively. Facial nerve paralysis (p = 0.007) and lymph node involvement (p = 0.006) were associated with decreased survival rates.
CONCLUSION
SCC of the temporal bone are rare but have a poor prognosis. Lymph node involvement and facial nerve palsy are associated with a poorer outcome. These tumors must initially be treated radically, for which an early diagnosis is important.
目的
本研究旨在分析过去15年在我科接受治疗的外耳道和中耳鳞状细胞癌（SCC）患者的治疗方法、预后变量及结果。
设计
对1990年至2006年间在我科接受治疗的19例患者进行回顾性分析。患者根据匹兹堡分类法进行分期。患者接受了外侧颞骨切除术（LTBR）或扩大颞骨切除术（全切除或次全切除）。对疑似有临床或影像学侵犯的患者进行了腮腺切除术，大多数晚期患者术后放疗作为辅助治疗。
结果
总体5年生存率为37%。I期无患者。II期、III期和IV期的生存率分别为100%、25%和16%。面神经麻痹（p = 0.007）和淋巴结受累（p = 0.006）与生存率降低相关。
结论
颞骨鳞状细胞癌罕见但预后较差。淋巴结受累和面神经麻痹与较差的预后相关。这些肿瘤最初必须进行根治性治疗，早期诊断对此很重要。
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