Ferdous Mehrabian, MD, Associate Professor of Obstetrics & Gynecology, Obstetrics & Gynecology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyyed Mohammad Hosseini, MD, Physician, Obstetrics & Gynecology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Pak J Med Sci. 2013 Jul;29(4):986-90. doi: 10.12669/pjms.294.4012.
To determine the association between high hemoglobin with gestational diabetes mellitus (GDM) and preeclampsia in pregnant women in the first trimester.
This cohort study was conducted among 973 pregnant women who started their antenatal booking in the first trimester (first 14 weeks of gestation). Women with first-visit high Hb levels (> 12.5 g/L) on first visit of the pregnancy period were selected as the study group and were compared with those who had normal Hb value (< 12.5 g/L) as controls. Adverse pregnancy outcomes including preeclampsia and GDM were compared between the two groups.
Complete obstetric records of 448 women with high Hb levels and 486 women with normal Hb levels were studied. The follow up showed that the women with high Hb levels had significantly higher rates of preeclampsia and GDM than those with normal Hb levels; the risks were 5.4 (95% cl; 2.8 to 10.5) and 3.7 (95%cl; 2.2 to 6.4), respectively.
This study found that high Hb in the first trimester is associated with higher risk of subsequent preeclampsia and gestational diabetes mellitus (GDM).
探讨孕早期血红蛋白（Hb）水平与妊娠期糖尿病（GDM）和子痫前期的相关性。
这是一项队列研究，纳入了 973 名在孕早期（妊娠 14 周内）进行产前检查的孕妇。将首次产检 Hb 水平升高（>12.5 g/L）的孕妇作为观察组，并与 Hb 水平正常（<12.5 g/L）的孕妇进行比较。比较两组孕妇的不良妊娠结局，包括子痫前期和 GDM。
对 448 例 Hb 水平升高的孕妇和 486 例 Hb 水平正常的孕妇进行了完整的产科记录研究。随访发现，Hb 水平升高的孕妇子痫前期和 GDM 的发生率显著高于 Hb 水平正常的孕妇，风险分别为 5.4（95%CI：2.8 至 10.5）和 3.7（95%CI：2.2 至 6.4）。
本研究发现，孕早期 Hb 水平升高与随后发生子痫前期和 GDM 的风险增加有关。
