Ma Ying, Ullrich Stephen E
Department of Immunology; The University of Texas MD Anderson Cancer Center; Houston, TX USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
Department of Immunology; The University of Texas MD Anderson Cancer Center; Houston, TX USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center; Houston, TX USA ; The University of Texas Graduate School of Biomedical Sciences at Houston; Houston, TX USA.
Oncoimmunology. 2013 Oct 1;2(10):e25964. doi: 10.4161/onci.25964. Epub 2013 Aug 2.
We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prolong the survival of tumor-bearing immunocompetent hosts.
我们最近发现,肥大细胞通过加剧促纤维增生性微环境中的细胞内和细胞外信号传导来促进胰腺肿瘤发生。我们的研究结果首次表明,靶向肥大细胞可阻断胰腺肿瘤的进展,并延长荷瘤免疫活性宿主的生存期。