孔源性视网膜脱离时视网膜下液中趋化因子CXCL-1的表达
Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment.
作者信息
Symeonidis Chrysanthos, Androudi Sofia, Rotsos Tryfon, Moschos Marilita M, Souliou Efimia, Dimitrakos Stavros A, Diza Eudoxia
机构信息
2nd Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital , Thessaloniki, Macedonia , Greece .
出版信息
Ocul Immunol Inflamm. 2014 Dec;22(6):449-53. doi: 10.3109/09273948.2013.863942. Epub 2013 Dec 19.
PURPOSE
To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment.
METHODS AND RESULTS
Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102 ± 37 pg/mL) were significantly higher (p = 0.050) compared to controls. CXCL-1 levels correlated significantly with age (p = 0.001) and RRD duration (p = 0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C.
CONCLUSIONS
The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR.
目的
研究孔源性视网膜脱离（RRD）期间视网膜下液（SRF）中趋化因子CXCL - 1的表达，并确定其与受累象限数和脱离持续时间之间的潜在相关性。
方法与结果
纳入标准为年龄18岁及以上且可能并发增殖性玻璃体视网膜病变（PVR）的原发性RRD患者。对36例RRD患者的36份SRF样本进行CXCL - 1水平检测。与对照组相比，CXCL - 1平均水平（102±37 pg/mL）显著更高（p = 0.050）。CXCL - 1水平与年龄（p = 0.001）和RRD持续时间（p = 0.002）显著相关。CXCL - 1最高水平与完全性RRD、29至60天的持续时间以及PVR C级相符。
结论
本研究结果可能有助于加深对CXCL - 1在RRD和PVR背景下伤口愈合过程的起始和进展中所起作用的理解。
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