从天然产物到药物：成为药物的天然产物实例。
From nature to market: examples of natural products that became drugs.
作者信息
de Fátima Angelo, Terra Bruna Silva, da Silva Cleiton Moreira, da Silva Daniel Leite, Araujo Debora Pereira, da Silva Neto Leonardo, Nascimento de Aquino Roney Anderson
机构信息
Grupo de Estudos em Química Organica e Biologica (GEQOB), Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
出版信息
Recent Pat Biotechnol. 2014;8(1):76-88. doi: 10.2174/1872208307666131220163108.
Nature is an irrefutable source of inspiration for the modern man in many aspects. The observation and understanding of nature have allowed the development of new materials, new sources of energies, new drugs etc. Specifically, natural products provide a great contribution to the development of new agents for the treatment of infections and antitumor agents. However, obtaining natural products directly from animals, fungi, bacteria, plants etc has been considered not enough to attend the high demand by pharmaceutical industries. In this regard, various strategies based on biotechnological processes or synthetic approaches have been developed. In this scenario the total synthesis can be undoubtedly a useful and powerful tool for obtaining higher amounts of natural products and/or structural modifications thereof. Herein, we emphasize successful examples of total synthesis of galanthamine, morphine, paclitaxel and podophyllotoxin - natural products approved as pharmaceuticals.
在许多方面，大自然是现代人无可辩驳的灵感源泉。对自然的观察与理解推动了新材料、新能源、新药物等的发展。具体而言，天然产物为开发抗感染新药和抗肿瘤药物做出了巨大贡献。然而，直接从动物、真菌、细菌、植物等获取天然产物被认为不足以满足制药行业的高需求。在这方面，基于生物技术过程或合成方法的各种策略已被开发出来。在这种情况下，全合成无疑是获得大量天然产物及其结构修饰的有用且强大的工具。在此，我们着重介绍加兰他敏、吗啡、紫杉醇和鬼臼毒素（已被批准作为药物的天然产物）全合成的成功案例。
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