Souza Juliana M DE, Galaverna Renan, Souza Aline A N DE, Brocksom Timothy J, Pastre Julio C, Souza Rodrigo O M A DE, Oliveira Kleber T DE
Department of Chemistry, Federal University of São Carlos, São Carlos, SP, Brazil.
Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.
An Acad Bras Cienc. 2018;90(1 Suppl 2):1131-1174. doi: 10.1590/0001-3765201820170778.
We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.
我们全面综述了连续流动化学在天然产物和药物合成方面的出现及其影响，这些产物是重要的药品，无疑引发了现代医疗保健领域的一场革命。我们详细介绍了现代药物的起源以及化学和微生物学方面的大规模批量生产模式。接着阐述了现代连续流动化学的引入，它既是推动有机化学发展的技术工具，也是一项基础研究工作。这部分详细介绍了生物活性天然产物和商业药物的合成。
