形成与紫外线诱导的二聚体嘧啶 DNA 损伤的直接修复。
Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions.
机构信息
Center for Integrated Protein Sciences at the Department of Chemistry, Ludwig-Maximilians Universität München, Munich, Germany.
出版信息
Photochem Photobiol. 2014 Jan;90(1):1-14. doi: 10.1111/php.12197. Epub 2013 Dec 2.
PMID:24354557
Abstract
Direct repair of UV-induced DNA lesions represents an elegant method for many organisms to deal with these highly mutagenic and cytotoxic compounds. Although the participating proteins are structurally well investigated, the exact repair mechanism of the photolyase enzymes remains a vivid subject of current research. In this review, we summarize and highlight the recent contributions to this exciting field.
摘要
直接修复紫外线诱导的 DNA 损伤是许多生物体应对这些高度诱变和细胞毒性化合物的一种优雅方法。尽管参与的蛋白质在结构上得到了很好的研究，但光解酶的精确修复机制仍然是当前研究的一个活跃课题。在这篇综述中，我们总结并强调了该领域的最新进展。
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