Department of Paediatrics, University of Dublin, Trinity College, National Children's Hospital, Tallaght, Dublin, Ireland.
Acta Paediatr. 2014 Jan;103(1):e38-42. doi: 10.1111/apa.12435. Epub 2013 Nov 11.
To describe bone mineral density at the lumbar spine in a group of girls with Turner's syndrome and determine its relation to pubertal development.
Girls with Turner's syndrome aged over 12 years were invited to participate in the study. All participants underwent auxology, pubertal assessment and laboratory evaluation. Bone mineral density was estimated by dual-energy X-ray absorptiometry. Bone mineral apparent density was then calculated, and the results were compared with age-matched Dutch reference data.
We studied 32 girls with Turner's syndrome, mean (SD) [range] age 16.7 (2.6) [12.4-20.2] years and height 148.3 (9.0) [126-159.2] cm. Bone mineral apparent density lumbar spine values were -0.87 SD, significantly lower than in the reference population (p <0.001). Bone mineral apparent density values were positively and significantly associated with breast Tanner stages and postmenarcheal status, but not spontaneous puberty. However, no significant association was found between bone mineral apparent density and karyotype, growth hormone or timing of oestrogen therapy.
Girls with Turner's syndrome have lower bone mineral apparent density values at the lumbar spine, even after correcting for size, compared with an age- and sex-matched general population. Pubertal development has significant impact on bone mineral apparent density in girls with Turner's syndrome.
描述特纳综合征女孩群体的腰椎骨矿物质密度，并确定其与青春期发育的关系。
邀请年龄超过 12 岁的特纳综合征女孩参加研究。所有参与者均接受人体测量学、青春期评估和实验室评估。通过双能 X 射线吸收法估计骨矿物质密度。然后计算骨矿物质表观密度，并将结果与年龄匹配的荷兰参考数据进行比较。
我们研究了 32 名特纳综合征女孩，平均（标准差）[范围]年龄 16.7（2.6）[12.4-20.2]岁，身高 148.3（9.0）[126-159.2]cm。腰椎骨矿物质表观密度值为-0.87 标准差，明显低于参考人群（p<0.001）。骨矿物质表观密度值与乳房 Tanner 分期和初潮后状态呈正相关且显著相关，但与自发性青春期无关。然而，骨矿物质表观密度与核型、生长激素或雌激素治疗时机之间未发现显著相关性。
与年龄和性别匹配的一般人群相比，即使校正了体型，特纳综合征女孩的腰椎骨矿物质表观密度值也较低。青春期发育对特纳综合征女孩的骨矿物质表观密度有显著影响。
