Vollmer Robin T
Laboratory Medicine (113), VAMC, Durham, NC, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
J Cutan Pathol. 2014 Mar;41(3):297-302. doi: 10.1111/cup.12280. Epub 2014 Jan 21.
Dermatopathologists know that the epidermis represents a dynamic compartment and that its cells mature from the basal layer to the skin surface in approximately 45 days. What may seem intuitive - but not obvious - is that the dynamics of the epidermis can affect the patterns of melanoma cells within the epidermis. Here this conjecture is explored with an abstract, theoretical model.
To control the independent effects of epidermal replacement velocity and thickness as well as rate of melanoma cell penetration of the epidermis, an abstraction of the epidermis was created and simulated via computer.
Simulated plots of the epidermis show that the number and pattern of melanoma cells in the epidermis is affected by the probability of melanoma cells entering the epidermis, by the velocity of epidermal replacement and by epidermal thickness.
This analysis suggests that the dynamics of the epidermis are sufficient to affect the patterns of melanoma cells within the epidermis.
皮肤病理学家知道表皮是一个动态的部分，其细胞从基底层到皮肤表面大约需要45天成熟。看似直观但并不明显的是，表皮的动态变化会影响表皮内黑色素瘤细胞的模式。在此，通过一个抽象的理论模型来探讨这一推测。
为了控制表皮更替速度、厚度以及黑色素瘤细胞穿透表皮的速率等独立影响因素，构建了一个表皮的抽象模型并通过计算机进行模拟。
表皮的模拟图显示，表皮内黑色素瘤细胞的数量和模式受到黑色素瘤细胞进入表皮的概率、表皮更替速度以及表皮厚度的影响。
该分析表明，表皮的动态变化足以影响表皮内黑色素瘤细胞的模式。
