Dy Lady C, Buckel Larry J, Hurwitz Robert M
Rush University Medical Center, Chicago, IL 60612, USA.
J Drugs Dermatol. 2007 Jul;6(7):708-11.
Since many studies have shown the discordant diagnoses of melanocytic lesions among pathologists despite the existence of an established histologic criteria, we sought to refine the histologic criteria by finding an additional reliable and reproducible objective histopathologic feature to aid in the diagnosis of melanoma in situ. We performed a retrospective analysis of 100 cases histologically diagnosed as melanoma in situ and compared them to a study control group consisting of junctional benign melanocytic nevi. The epidermis of all the melanocytic lesions was examined for epidermal effacement. Examination of the epidermis in the study group revealed an absence of epidermal effacement in only 7 (10%) cases, whereas 93 (93%) cases showed an absence of rete ridges in some foci, making this an overwhelming majority finding in the cases examined. These results serve as a compelling adjunctive finding that can be used to increase the histologic diagnostic accuracy of melanoma in situ.
尽管存在既定的组织学标准，但许多研究表明病理学家对黑素细胞病变的诊断存在不一致。因此，我们试图通过寻找另一种可靠且可重复的客观组织病理学特征来完善组织学标准，以辅助原位黑素瘤的诊断。我们对100例经组织学诊断为原位黑素瘤的病例进行了回顾性分析，并将其与一个由交界性良性黑素细胞痣组成的研究对照组进行比较。对所有黑素细胞病变的表皮进行了表皮消蚀检查。研究组表皮检查显示，仅7例（10%）病例无表皮消蚀，而93例（93%）病例在某些病灶处无 rete 嵴，这在检查的病例中是压倒性的多数发现。这些结果是一个有说服力的辅助发现，可用于提高原位黑素瘤的组织学诊断准确性。
