Department of Surgery, Division of Transplantation, Hospital of the University of Pennsylvania, Philadelphia, PA.
Am J Transplant. 2014 Jan;14(1):216-20. doi: 10.1111/ajt.12504. Epub 2013 Nov 13.
Living donor liver transplantation (LDLT) demands a careful assessment of abnormal findings discovered during the evaluation process to determine if there will be any potential risks to the donor or recipient. Varying degrees of elevated hepatic iron levels are not uncommonly seen in otherwise healthy individuals. We questioned whether mild expression of hemosiderin deposition presents a safety concern when considering outcomes of living donation for both the donor and the recipient. We report on three LDLT patients who were found to have low- to moderate-grade hemosiderin deposition on liver biopsy. All other aspects of their evaluation proved satisfactory, and the decision was made to proceed with donation. There were no significant complications in the donors, and all demonstrated complete normalization of liver function postoperatively, with appropriate parenchymal regeneration. The recipients also had unremarkable postoperative recovery. We conclude that these individuals can be considered as potential donors after careful evaluation.
活体肝移植 (LDLT) 需要仔细评估评估过程中发现的异常发现，以确定供体或受体是否存在任何潜在风险。在其他方面健康的个体中，不同程度的肝铁水平升高并不少见。我们质疑在考虑供体和受体的活体捐献结果时，轻度表达含铁血黄素沉积是否存在安全问题。我们报告了 3 例 LDLT 患者，他们的肝活检显示低至中度含铁血黄素沉积。他们评估的所有其他方面都令人满意，决定进行捐献。供体没有出现明显并发症，所有供体术后肝功能均完全正常，实质再生适当。受者术后恢复也无明显异常。我们的结论是，这些个体在经过仔细评估后可以被视为潜在的供体。
