Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania; Fertility Center, York, Pennsylvania.
Fertil Steril. 2014 Mar;101(3):676-82. doi: 10.1016/j.fertnstert.2013.11.022. Epub 2013 Dec 17.
To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.
Prospective cohort study.
Academic IVF center.
PATIENT(S): One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and spontaneous abortion rates were collected.
RESULT(S): Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.
CONCLUSION(S): Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.
评估拮抗剂方案中取卵日 P 水平的分布与妊娠结局的关系，因为拮抗剂方案可能存在 P 水平升高的风险。
前瞻性队列研究。
学术 IVF 中心。
186 名接受拮抗剂方案控制性卵巢刺激的妇女。
无。
收集胚胎着床、妊娠和自然流产率。
取卵日 P 水平<12ng/mL 时，胚胎着床率（胚胎移植后 14 天 hCG 阳性）和妊娠率显著升高。当 P 水平≥12ng/mL 时，流产率较高，但差异无统计学意义。
取卵日 P 水平升高与胚胎着床和持续妊娠率显著降低相关。这是迄今为止第一项研究，既揭示了拮抗剂周期中取卵日 P 水平的分布，又确定了升高对妊娠结局的影响。
Zotero 插件