Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Reproductive Medicine Center, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Endocrinol (Lausanne). 2023 Feb 23;14:1086998. doi: 10.3389/fendo.2023.1086998. eCollection 2023.
The aim of this study was to determine whether, on the day of human chorionic gonadotropin (hCG) injection, the progesterone to number of mature oocytes index (PMOI) can be used alone or together with other parameters in a fresh embryo transfer fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycle to predict pregnancy outcome.
This was a retrospective cohort study of all couples who underwent a clinical pregnancy and received a fresh IVE/ICSI cycle at a single large reproductive medical center between June 2019 and March 2022. The study involved a total of 1239 cycles. To analyze risk factors associated with pregnancy outcomes on the day of HCG injection, univariate and multivariate logistic regression analyses were used. The area under the curve (AUC) was determined, and PMOI and other factors were compared using receiver operating characteristic (ROC) curves.
The clinical pregnancy rate was significantly higher in group A (60.76%) than in the other groups (Group B: 52.92% and Group C:47.88%, respectively, p =0.0306). Univariate and multivariate logistic regression revealed that PMOI levels were significantly correlated with the probability of pregnancy outcome, independent of other risk factors. More importantly, PMOI levels independently predict the occurrence of pregnancy outcome, comparable to the model combining age. The optimal serum PMOI cutoff value for pregnancy outcome was 0.063 ug/L.
Our results suggest that PMOI levels have an independent predictive value for pregnancy outcome in fresh IVF/ICSI cycles.
本研究旨在确定在人绒毛膜促性腺激素（hCG）注射日，孕酮与成熟卵母细胞数指数（PMOI）是否可单独或与新鲜胚胎移植受精（IVF）/卵胞浆内单精子注射（ICSI）周期中的其他参数一起用于预测妊娠结局。
这是一项回顾性队列研究，纳入了 2019 年 6 月至 2022 年 3 月在一家大型生殖医学中心接受新鲜 IVF/ICSI 周期的所有夫妇。该研究共涉及 1239 个周期。为了分析 hCG 注射日与妊娠结局相关的风险因素，采用单变量和多变量逻辑回归分析。确定曲线下面积（AUC），并使用受试者工作特征（ROC）曲线比较 PMOI 和其他因素。
A 组（60.76%）的临床妊娠率明显高于 B 组（52.92%）和 C 组（47.88%，p=0.0306）。单变量和多变量逻辑回归显示，PMOI 水平与妊娠结局的概率显著相关，独立于其他风险因素。更重要的是，PMOI 水平独立预测妊娠结局的发生，与年龄模型相当。预测妊娠结局的最佳血清 PMOI 截断值为 0.063ug/L。
我们的研究结果表明，PMOI 水平对新鲜 IVF/ICSI 周期的妊娠结局具有独立的预测价值。
