University Institute of Pharmacy, Raipur, Pt. Ravishankar Shukla University, Chhattisgarh 492010, India.
Ageing Res Rev. 2014 Jan;13:65-74. doi: 10.1016/j.arr.2013.12.001. Epub 2013 Dec 16.
The continuous exposure of skin to ultraviolet radiations generates reactive oxygen species leading to photoaging in which degradation of dermal collagen and degeneration of elastic fibers occurs. Matrix metalloproteinase [MMP] enzymes are the proteolytic enzymes which have significant potentiality of cleaving extracellular matrix [ECM] against Ultraviolet [UV] radiation. The important MMPs are MMP1, MMP2 and MMP7 which promote skin cancer when irradiated by UV rays. In lieu of this, the investigation of MMPs and their inhibitors are constantly being studied for successive results. Recent researches have focused on some traditionally used bioactive moieties as natural matrix metalloproteinases inhibitors (MMPIs) and emphasized on the need of more extensive and specific studies on MMPIs, so that a good combination of natural or synthetic MMPIs with the conventional drugs can be evolved for cancer chemotherapy. In this review, we discuss the current view on the feasibility of MMPs as targets for therapeutic intervention in cancer. This review also summarizes the role of small molecular weight natural MMPIs and a clinical update of those natural MMPIs that are under clinical trial stage.
皮肤持续暴露于紫外线辐射会产生活性氧物种，导致光老化，使真皮胶原降解和弹性纤维变性。基质金属蛋白酶[MMP]酶是具有显著潜力的蛋白水解酶，可以分解细胞外基质[ECM]对抗紫外线[UV]辐射。重要的 MMP 是 MMP1、MMP2 和 MMP7，它们在受到 UV 射线照射时会促进皮肤癌的发生。有鉴于此，人们一直在研究 MMP 及其抑制剂，以期取得更多的研究成果。最近的研究集中在一些传统使用的生物活性基团作为天然基质金属蛋白酶抑制剂（MMPI）上，并强调需要对 MMPIs 进行更广泛和具体的研究，以便将天然或合成 MMPIs 与传统药物进行良好的结合，用于癌症化疗。在这篇综述中，我们讨论了将 MMP 作为癌症治疗干预靶点的可行性。这篇综述还总结了小分子天然 MMPIs 的作用以及那些处于临床试验阶段的天然 MMPIs 的临床最新进展。
