Fardet A, Rock E
INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
Med Hypotheses. 2014 Feb;82(2):181-6. doi: 10.1016/j.mehy.2013.11.035. Epub 2013 Dec 6.
The study of micronutrient and phytochemical (MaP, i.e., non-energy nutrients) bioavailability has been mainly studied through a reductionist and pharmacological approach. This has led to associate one health effect to one MaP. However, human interventional studies have given conflicting and disappointing results about MaP supplementation. This is because the health effect is the result of the synergetic action of numerous MaPs supplied by foods and/or diets at nutritional doses. A food is not a drug. Therefore, there is a need for more holistic approach to study MaP bioavailability, then their health effect to achieve general recommendations. This paper aims to hypothesize for such a paradigm shift in this topic and to lay new foundations for research in MaP bioavailability.
微量营养素和植物化学物质（MaP，即非能量营养素）生物利用度的研究主要是通过还原论和药理学方法进行的。这导致将一种健康效应与一种MaP联系起来。然而，人体干预研究关于MaP补充剂给出了相互矛盾且令人失望的结果。这是因为健康效应是由食物和/或饮食以营养剂量提供的多种MaP协同作用的结果。食物不是药物。因此，需要一种更全面的方法来研究MaP生物利用度，进而研究它们对健康的影响，以实现一般性建议。本文旨在对该主题的这种范式转变提出假设，并为MaP生物利用度的研究奠定新的基础。
