Guo Wenqian, Ma Han, Wang Chong-Zhi, Wan Jin-Yi, Yao Haiqiang, Yuan Chun-Su
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
Front Pharmacol. 2021 Dec 7;12:790321. doi: 10.3389/fphar.2021.790321. eCollection 2021.
Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.
关于DNA甲基化参与众多细胞过程和多种人类疾病，已积累了大量知识；然而，很少有研究探讨DNA甲基化在中国草药（CHM）中的多效性作用。CHM已在全球范围内用于多种疾病的预防和治疗。新开发的表观遗传技术为CHM的发展带来了巨大机遇。在本综述中，我们总结了DNA甲基化研究，并描绘了DNA甲基化在中国草药中的多效性作用。DNA甲基化作为一种介质，参与植物对环境因素的反应，从而影响对治疗效果至关重要的CHM药用植物生长和生物活性化合物生物合成。此外，DNA甲基化有助于揭示CHM配方、草药和草药衍生化合物的药理机制。它还为CHM的体质理论和其他重要问题提供科学验证。这个新发展的DNA甲基化领域正在兴起，以解决CHM的许多复杂科学问题；因此，它不仅促进疾病治疗，还有助于健康维护。
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