IL-36 细胞因子的生物学特性及其在疾病中的作用。
Biology of IL-36 cytokines and their role in disease.
机构信息
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), The Netherlands.
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), The Netherlands; Department of Medicine, University of Colorado Denver, Aurora, CO, USA.
出版信息
Semin Immunol. 2013 Dec 15;25(6):458-65. doi: 10.1016/j.smim.2013.11.003. Epub 2013 Dec 17.
IL-36α, IL-36β, IL-36γ, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36α, IL-36β, and IL-36γ are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling. IL-36 cytokines require processing in order to become fully active, however the protease(s) responsible for this are currently not known. The IL-36 receptor pathway activates dendritic cells and plays a role in polarizing T-helper responses. The skin is the predominant site where IL-36 cytokines are expressed and several reports have established that they play a significant role in the pathogenesis of skin diseases. In this review the discovery and biological function of the cytokines IL-36α, IL-36β, IL-36γ and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases.
IL-36α、IL-36β、IL-36γ 和 IL-36Ra 统称为 IL-36 细胞因子，是 IL-1 家族的一部分。IL-36α、IL-36β 和 IL-36γ 是 IL-36 受体（IL-36R）激动剂，而 IL-36Ra 是受体拮抗剂，可阻断 IL-36R 信号的激活。IL-36 细胞因子需要经过加工才能充分激活，但目前尚不清楚负责这种加工的蛋白酶。IL-36 受体途径激活树突状细胞，并在 T 辅助反应的极化中发挥作用。皮肤是表达 IL-36 细胞因子的主要部位，有几项报告表明它们在皮肤病的发病机制中发挥着重要作用。在这篇综述中，将讨论细胞因子 IL-36α、IL-36β、IL-36γ 和 IL-36Ra 的发现和生物学功能，以及它们在各种疾病发病机制中的作用。
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